![]() Let us know how this access is important for you. Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. We considered different values of the scaled selection intensity and the time since the fixation of the positively selected allele. We provide evidence of one of the strongest selective sweeps reported in humans this sweep has driven this variant to high frequency in circum-Arctic populations within the last 6-23 ka despite associated deleterious consequences, possibly as a result of the selective advantage it originally provided to either a high-fat diet or a cold environment. We performed computer simulations to assess the ability of the various HMM methods to detect a selective sweep ( Tables 13 ). Remarkably, the derived allele is associated with hypoketotic hypoglycemia and high infant mortality yet occurs at high frequency in Canadian and Greenland Inuits and was also found at 68% frequency in our Northeast Siberian sample. Here, using whole-genome high-coverage sequence data, we identified the most likely causative variant as a nonsynonymous G>A transition (rs80356779 c.1436C>T on the reverse strand) in CPT1A, a key regulator of mitochondrial long-chain fatty-acid oxidation. Maynard Smith and Haigh 79 showed that as an advantageous mutation rises in. However, it was not possible to determine which of the genes might be driving the selection signal. Download scientific diagram Selective sweeps and background selection. ![]() Therefore the selective sweep in the MHC class. Genome-wide selection scans based on genotype data from native Siberians have previously highlighted a 3 Mb chromosome 11 region containing 79 protein-coding genes as the strongest candidates for positive selection in Northeast Siberians. The loss of variability predates the (sub)speciation of chimpanzees and did not effect other known gene systems. Arctic populations live in an environment characterized by extreme cold and the absence of plant foods for much of the year and are likely to have undergone genetic adaptations to these environmental conditions in the time they have been living there. ![]()
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